Conjugating a groove-binding motif to an Ir(iii) complex for the enhancement of G-quadruplex probe behavior† †Electronic supplementary information (ESI) available: Compound characterisation and supplementary data. See DOI: 10.1039/c6sc00001k Click here for additional data file.

نویسندگان

  • Modi Wang
  • Zhifeng Mao
  • Tian-Shu Kang
  • Chun-Yuen Wong
  • Jean-Louis Mergny
  • Chung-Hang Leung
  • Dik-Lung Ma
چکیده

a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. Email: [email protected] bState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. Email: [email protected] cDepartment of Biology and Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong, China dUniversity of Bordeaux, ARNA laboratory, Bordeaux, France. Email: [email protected] eINSERM, U869, IECB, Pessac, France.

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Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe† †Electronic supplementary information (ESI) available: Compound characterisation and supplementary data. See DOI: 10.1039/c4sc03319a Click here for additional data file.

A series of luminescent Ir(III) complexes were synthesised and evaluated for their ability to act as luminescent G-quadruplex-selective probes. The Ir(III) complex 9, [Ir(phq)2(phen)]PF6 (where phq 1⁄4 2-phenylquinoline; phen 1⁄4 1,10-phenanthroline), exhibited high luminescence in the presence of G-quadruplex DNA compared to dsDNA and ssDNA, and was employed to construct a label-free G-quadrup...

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Department of Chemistry, Hong Kong Bapti China. E-mail: [email protected] State Key Laboratory of Quality Research i Medical Sciences, University of Macau, Ma mo University of Bordeaux, ARNA Laboratory [email protected] INSERM, U869, IECB, Pessac, France Partner State Key Laboratory of Environme Baptist University, Kowloon Tong, Hong Kon † Electronic supplementary informa characterisation and...

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عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2016